Our research axes:

  • Identify the bases of rare genetic diseases with development disorders

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  • Understand the physiopathology of certain development
    diseases

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  • Set up genomic medicine in development disorders

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The "Genetics of development disorders" team (GAD) INSERM 1231

The GAD team was evaluated by the AERES in 2010 and created as an emergent team of the University of Burgundy in January 2011 in the context of the 2012-2016 four-year report.

This research team was created to pursue the themes already initiated at Dijon CHU, by allowing the development of new more ambitious research projects around rare genetic diseases with development disorders, and the involvement of students. Accreditation as a Reference Centre for Rare Diseases by the Ministry of Health in the framework of the 2006 Rare Diseases Plan on the theme of development disorders and malformation syndromes, bringing together the Genetics departments several university hospitals of eastern France and coordinated by Pr. Olivier-Faivre in Dijon, was a determining factor in this project. This team wished to be part of the high-throughput sequencing revolution by developing projects to identify genes responsible for rare diseases, and in parallel to accumulate expertise in physiopathology studies in certain chosen themes. This research team includes teacher-researchers and researchers of the University Hospitals and Universities of Burgundy-Franche-Comté. For this dimension, the team welcomed Dr. Jean-Baptiste Rivière, an expert in next-generation sequencing, from September 2012 to September 2015, before he returned to Quebec (Mc Gill Université).

The GAD team is now part of the Fédération Hospitalo Universitaire TRANSLAD, accredited in September 2013, which is a genomic innovation project for the benefit of patients and their families. The FHU-TRANSLAD was given 1st place by an international jury following a call for projects launched jointly by university hospitals and universities of the Burgundy-Franche Comté region with the aim to promote projects of excellence that were both federating and innovative.

Since 2014, the coordinators of the GAD team have also been responsible for running the national healthcare network devoted to development disorders and intellectual deficiency (AnDDI-Rares), which brings together reference centers, skills centers, diagnostic and research laboratories, and associations of patients on the theme.

In 2015, the team completed its first valorization project by setting up Orphanomix, the busness unit of the GAD team, jointly with the SATT Grand-Est.

After a very positive evaluation in 2016, the team joined the Inserm Research Center UMR 1231 on 1st January 2017.

Partners

  • CHU de Dijon
  • CHU de Besançon
  • Ministère de l'Enseignement supérieur et de la Recherche
  • Conseil régional de Bourgogne
  • FECLAD
  • Université de Bourgogne Franche-Comté
  • INSERM
  • Fondation maladies rares
  • Translad